Balanced discussion of second-generation antihistamines’ data
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چکیده
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Comparative Effect of Newer Antihistamines on Psychomotor Functions in Indian Population
The purpose of the present study was to comparatively evaluate the effect of newer antihistamines on psychomotor functions in Indian population. Seventy five patient volunteers were included in the study. Volunteers were put into 5 groups based on the type of antihistamine prescribed. Group-1 volunteers included those who were prescribed no antihistamine, group-2 were prescribed first generatio...
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OBJECTIVES To perform a critical evaluation of the more recent H1 antihistamines and the various terms used to describe them, based on a review of evidence on their role in the treatment of allergic disorders. SOURCES OF DATA Original articles, reviews and consensus documents published from 1998 to 2006 and indexed in the MEDLINE and PubMed databases. Keyword: antihistamines. SUMMARY OF THE...
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BACKGROUND Antihistamines are among the most frequently used medications in the United States. Despite dramatically higher cost, second-generation antihistamines are replacing diphenhydramine because of the perception that they are not constrained by its sedating effects. OBJECTIVE We sought to examine, through meta-analytic procedures, the collective evidence regarding the sedating and perfo...
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This article reviews the molecular biology of the interaction of histamine with its H1-receptor and describes the concept that H1-antihistamines are not receptor antagonists but are inverse agonists i.e. they produce the opposite effect on the receptor to histamine. It then discourages the use of first-generation H1-antihistamines in clinical practice today for two main reasons. First, they are...
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QUESTION Many of my pregnant and breastfeeding patients suffer from allergies and frequently ask me about the safety of antihistamines during pregnancy and breastfeeding. Should I advise them to use the older sedating medications? I have heard that they might be safer than the newer nonsedating class of drugs. Or have the newer ones been studied as well? ANSWER First-generation antihistamines...
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